The aim of this study was to assess the effect of doxycycline monohydrate on the growth ofP. aeruginosain the presence of bacterial nitrofurantoin.
The study was conducted as a prospective, randomized clinical trial. Twenty-two men and seven women participated in the study. All patients received doxycycline monohydrate (150 mg/d,N= 22; placebo, 20 mg/d), doxycycline, doxycycline + oxytetracycline (25 mg/d,= 19; doxycycline + oxytetracycline, 10 mg/d), and placebo for 8 weeks. All patients received doxycycline monohydrate in a 2:1 ratio for 7 weeks (n=10). Doxycycline monohydrate was administered once daily for 10 days at a dose of 100 mg/d. For the 7-day treatment, the patients were required to drink a glass of water (20 ml). Patients were instructed to complete the questionnaire, complete the questionnaire, and complete the blood culture test within 24 hours after the last dose of doxycycline, during which they were instructed to continue taking the antibiotic until the end of the 7-day treatment. The primary end point was the change from the baseline of the number of days of treatment with doxycycline in the 7-day treatment group, as assessed by the number of days with a change from baseline in the number of days with a decrease from baseline to the end of the treatment group (see Table ).
Statistical analysis was performed using the Sigma statistical package for the social sciences (SAS) version 12.0 (SAS Institute Inc., Cary, NC, USA).P< 0.05 was considered statistically significant.
Figure 1Comparison of the growth ofin the presence of doxycycline monohydrate in the presence of bacterial nitrofurantoin.
Figure 2Treatment effects of doxycycline monohydrate on the growth of
Figure 3Effect of doxycycline monohydrate on growth of
Figure 4Treatment effects of doxycycline monohydrate on growth of
Figure 5Effect of doxycycline monohydrate on the number of days with decrease from baseline in the number of days with a decrease from baseline to the end of the treatment group.
Statistical analysis was performed using the Sigma statistical package for the social sciences version 12.0 (SAS Institute Inc., Cary, NC, USA).
The following variables were recorded for the patients included in the statistical analysis: age, sex, BMI, waist circumference (WC), height (HD), and height ratio (HRA).
The following variables were recorded for the patients included in the statistical analysis: BMI, waist circumference (WC), height (HD), and height ratio (HRA).
The following variables were recorded for the patients included in the statistical analysis: age, sex, BMI, WC, HRA, HCT, and T-2-score, and WC (≥2cm), BMI (≤2cm), waist circumference (WC), and WC (≥2cm), height (HD), and height ratio (HRA), respectively.
Yes, Doxycycline capsules can be effective in treating acne. They are commonly prescribed by healthcare professionals for moderate to severe acne cases. Doxycycline is an antibiotic that works by reducing inflammation and controlling the growth of bacteria associated with acne.
Doxycycline helps to improve acne symptoms by:
Reducing inflammation: Doxycycline has anti-inflammatory properties that can help reduce the redness, swelling, and tenderness associated with acne.
Controlling bacterial growth: Acne is often caused by the overgrowth of bacteria on the skin, particularly a type of bacteria called Propionibacterium acnes. Doxycycline works by inhibiting bacterial protein synthesis, thereby controlling the growth and spread of these bacteria.
Regulating oil production: Doxycycline can also help regulate sebum (oil) production in the skin, which is a contributing factor in the development of acne.
You should combine systemic antibiotics such as doxycycline or capsules (both contraindicated in pregnancy and children under 12 years of age) with an appropriate topical agent such as or or. You should ideally continue treatment for 3 months.
How to split a Doxycycline capsule (Doxycycline 100mg) into 3 equal doses:The amount of Doxycycline that you need to take is based on your medical condition and response to treatment.
If you are taking Doxycycline with or without food, take the Doxycycline dose mentioned above as a whole. In this case, the Doxycycline dose should be taken at the same time each day. You should take it regularly to and from your acne treatment.
Doxycycline with an oil:
To ensure a correct dose, follow the directions given to you by your doctor or pharmacist.
Doxycycline with an oil concentration of more than 80% can be taken before an acne break and with a limited daily supply.2
Always follow your doctor’s instructions when taking Doxycycline with an oil concentration of 80% or more.3
2. Follow the directions for use:
Take Doxycycline with or without food as directed by your doctor or pharmacist, and do not exceed the prescribed dosage. Doxycycline is usually taken with food or a nutrient-rich diet.3,4 The dosing cup should be kept on a flat area in order to be taken at the same time each day.3 Keep away from children and brokenacea.
3. Use the cup with your food or another drink with you:
For moderate to severe acne:
3–4 The recommended adult dose is 100mg taken before an acne break and with a limited daily supply.3,4 You should avoid using a canister of Doxycycline if you have had brokenacea in the past or have liver or kidney disease.4 Doses can be taken with or without food; however, the recommended dose is 100mg once daily, which may be increased to tripled doses if necessary.3,4
Keep out of reach of children:
3.1 If you are taking systemic antibiotics such as doxycycline or capsules (both contraindicated in pregnant women) and an oil concentration of 80% or more, you can take it at a same time each day.3,4
3.2 If you are taking systemic antibiotics such as doxycycline or capsules (both contraindicated in pregnant women) and an oil concentration of 80% or more, you can take it at a same time each day.3,4,5
3.3 If you are taking systemic antibiotics such as doxycycline or capsules (both contraindicated in nursing women) and an oil concentration of 80% or more, you can take it at a same time each day.3,4,5
3.4 If you are taking systemic antibiotics such as doxycycline or capsules (both contraindicated in pregnant women) and an oil concentration of 80% or more, you can take it at a same time each day.3,4,5
3.5 If you are taking systemic antibiotics such as doxycycline or capsules (both contraindicated in nursing women) and an oil concentration of 80% or more, you can take it at a same time each day.3,4,5
tell your doctor and pharmacist if you are allergic to doxycycline, minocycline, tetracycline, demeclocycline, any other medications, sulfites, or any of the ingredients in doxycycline capsules, extended-release capsules, tablets, extended-release tablets, or suspension. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acitretin (Soriatane); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); barbiturates such as butabarbital (Butisol), phenobarbital, and secobarbital (Seconal); bismuth subsalicylate; carbamazepine (Epitol, Tegretol, others); isotretinoin (Absorica, Amnesteem, Clavaris, Myorisan, Zenatane); penicillin; phenytoin (Dilantin, Phenytek); and proton pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabeprazole (Aciphex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with doxycycline, making it less effective. Take doxycycline 2 hours before or 6 hours after taking antacids, calcium supplements, and laxatives containing magnesium. Take doxycycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron.
tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, blurry or double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, surgery on your stomach, asthma, or kidney or liver disease.
you should know that doxycycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking doxycycline, call your doctor immediately. Doxycycline can harm the fetus.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxycycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
you should know that when doxycycline is used during pregnancy or in babies or children up to 8 years of age, it can cause the teeth to become permanently stained. Doxycycline should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.
do not use doxycycline capsules, tablets, or injections on your own, unless your doctor tells you to.
doxycycline capsules, tablets, extended-release tablets, or suspension you must be treated with doxycycline.
tell your doctor and pharmacist if you are allergic to doxycycline, minocycline, tetracycline, demeclocycline, any other medications, sulfites, or any of the ingredients in doxycycline capsules, extended-release capsules, tablets, extended-release tablets, or suspension. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acitretin (Soriatane); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); barbiturates such as butabarbital (Butisol), phenobarbital, and secobarbital (Seconal); bismuth subsalicylate; carbamazepine (Epitol, Tegretol, others); isotretinoin (Absorica, Amnesteem, Clavaris, Myorisan, Zenatane); penicillin; phenytoin (Dilantin, Phenytek); and proton pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabeprazole (Aciphex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with doxycycline, making it less effective. Take doxycycline 2 hours before or 6 hours after taking antacids, calcium supplements, and laxatives containing magnesium. Take doxycycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron.
tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, blurry or double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, surgery on your stomach, asthma, or kidney or liver disease.
you should know that doxycycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking doxycycline, call your doctor immediately. Doxycycline can harm the fetus.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxycycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
you should know that when doxycycline is used during pregnancy or in babies or children up to 8 years of age, it can cause the teeth to become permanently stained. Doxycycline should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.
Doxycycline is used to treat a variety of bacterial infections, including those that cause acne. It may be prescribed for other infections as determined by your doctor.
Doxycycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). You may want to speak with your doctor about changing the doses or switching to a different form of birth control.
Doxycycline should not be used for more than 2 infections a day.
Do not share Doxycycline with any other who have the infection.
In some countries doxycycline may be used to treat acne.
Resverified:
Treatment with Doxycycline may be limited due to side effects such as headache, nausea, and stomach upset.
Doxycycline is available in both tablet and capsule form.
Store at room temperature. Do not store above 25°C.
Do not freeze.